Structure of DNA methyltransferases DNMT3A/DNMT3B bound to a nucleosome

CpG methylation by the de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated in cancer(1). These two DNMTs preferentially bind to nucleosomes yet cannot methylate the DNA wrapped around the nucleosome core(2), and f...

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Pubblicato in:Nature
Autori principali: Xu, Ting-Hai, Liu, Minmin, Zhou, X. Edward, Liang, Gangning, Zhao, Gongpu, Xu, H. Eric, Melcher, Karsten, Jones, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540737/
https://ncbi.nlm.nih.gov/pubmed/32968275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2747-1
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