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Structure of DNA methyltransferases DNMT3A/DNMT3B bound to a nucleosome
CpG methylation by the de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated in cancer(1). These two DNMTs preferentially bind to nucleosomes yet cannot methylate the DNA wrapped around the nucleosome core(2), and f...
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| Publicat a: | Nature |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7540737/ https://ncbi.nlm.nih.gov/pubmed/32968275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2747-1 |
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