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p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes

DNA methylation and histone tail modifications are interrelated mechanisms involved in a wide range of biological processes, and disruption of this crosstalk is linked to diseases such as acute myeloid leukemia. In addition, DNA methyltransferase 3A (DNMT3A) activity is modulated by several regulato...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Sandoval, Jonathan E., Reich, Norbert O.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948466/
https://ncbi.nlm.nih.gov/pubmed/33172892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016125
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