Fluorine‐Induced Pseudo‐Anomeric Effects in Methoxycyclohexanes through Electrostatic 1,3‐Diaxial Interactions

We report counter‐intuitive axial preferences in non‐stereochemically biased, selectively fluorinated methoxycyclohexanes. These pseudo‐anomeric effects are apparent when electronegative CF(2) groups are placed at the C‐2, C‐4 and C‐6 positions of the cyclohexane ring to render the C‐3/5 axial hydro...

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Vydáno v:Chemistry
Hlavní autoři: Piscelli, Bruno A., Sanders, William, Yu, Cihang, Al Maharik, Nawaf, Lebl, Thomas, Cormanich, Rodrigo A., O'Hagan, David
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540582/
https://ncbi.nlm.nih.gov/pubmed/32588927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003058
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