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Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif

This paper reports the synthesis of three amine stereoisomers 5a–c of the tetrafluorocyclohexyl ring system, as building blocks for discovery chemistry programmes. The synthesis starts from a Birch reduction of benzonitrile, followed by an in situ methyl iodide quench. The resultant 2,5-cyclohexadie...

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Detalles Bibliográficos
Publicado en:Beilstein J Org Chem
Main Authors: Bykova, Tetiana, Al-Maharik, Nawaf, Slawin, Alexandra M Z, O'Hagan, David
Formato: Artigo
Idioma:Inglês
Publicado: Beilstein-Institut 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405691/
https://ncbi.nlm.nih.gov/pubmed/28503208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.72
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