Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gα(q) Protein Inhibitors in Biological Samples

The cyclic depsipeptide FR900359 (FR) isolated from the plant Ardisia crenata and produced by endosymbiotic bacteria acts as a selective Gq protein inhibitor. It is a powerful tool to study G protein-coupled receptor signaling, and has potential as a novel drug for the treatment of pulmonary disease...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Kuschak, Markus, Schlegel, Jonathan G., Schneider, Marion, Kehraus, Stefan, Voss, Jan H., Seidinger, Alexander, Matthey, Michaela, Wenzel, Daniela, Fleischmann, Bernd K., König, Gabriele M., Müller, Christa E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540253/
https://ncbi.nlm.nih.gov/pubmed/33173765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00833
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