Cell‐permeable high‐affinity tracers for G(q) proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors

BACKGROUND AND PURPOSE: G proteins are intracellular switches that transduce and amplify extracellular signals from GPCRs. The G(q) protein subtypes, which are coupled to PLC activation, can act as oncogenes, and their expression was reported to be up‐regulated in cancer and inflammatory diseases. G...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Kuschak, Markus, Namasivayam, Vigneshwaran, Rafehi, Muhammad, Voss, Jan H., Garg, Jaspal, Schlegel, Jonathan G., Abdelrahman, Aliaa, Kehraus, Stefan, Reher, Raphael, Küppers, Jim, Sylvester, Katharina, Hinz, Sonja, Matthey, Michaela, Wenzel, Daniela, Fleischmann, Bernd K., Pfeifer, Alexander, Inoue, Asuka, Gütschow, Michael, König, Gabriele M., Müller, Christa E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070167/
https://ncbi.nlm.nih.gov/pubmed/31881095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14960
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