Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890–Fit for Translation?

[Image: see text] Guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by G protein-coupled receptors (GPCRs) to intracellular signaling cascades. While GPCRs represent the largest class of drug targets, G protein inhibition has only recently been recognized as a...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Schlegel, Jonathan G., Tahoun, Mariam, Seidinger, Alexander, Voss, Jan H., Kuschak, Markus, Kehraus, Stefan, Schneider, Marion, Matthey, Michaela, Fleischmann, Bernd K., König, Gabriele M., Wenzel, Daniela, Müller, Christa E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033771/
https://ncbi.nlm.nih.gov/pubmed/33860209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00021
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