The experimental power of FR900359 to study Gq-regulated biological processes

Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. Using a multifaceted approach we systemati...

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Detalhes bibliográficos
Publicado no:Nat Commun
Principais autores: Schrage, Ramona, Schmitz, Anna-Lena, Gaffal, Evelyn, Annala, Suvi, Kehraus, Stefan, Wenzel, Daniela, Büllesbach, Katrin M., Bald, Tobias, Inoue, Asuka, Shinjo, Yuji, Galandrin, Ségolène, Shridhar, Naveen, Hesse, Michael, Grundmann, Manuel, Merten, Nicole, Charpentier, Thomas H., Martz, Matthew, Butcher, Adrian J., Slodczyk, Tanja, Armando, Sylvain, Effern, Maike, Namkung, Yoon, Jenkins, Laura, Horn, Velten, Stößel, Anne, Dargatz, Harald, Tietze, Daniel, Imhof, Diana, Galés, Céline, Drewke, Christel, Müller, Christa E., Hölzel, Michael, Milligan, Graeme, Tobin, Andrew B., Gomeza, Jesús, Dohlman, Henrik G., Sondek, John, Harden, T. Kendall, Bouvier, Michel, Laporte, Stéphane A., Aoki, Junken, Fleischmann, Bernd K., Mohr, Klaus, König, Gabriele M., Tüting, Thomas, Kostenis, Evi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682109/
https://ncbi.nlm.nih.gov/pubmed/26658454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10156
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