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The experimental power of FR900359 to study Gq-regulated biological processes
Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. Using a multifaceted approach we systemati...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4682109/ https://ncbi.nlm.nih.gov/pubmed/26658454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10156 |
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