Hypertonic saline mediates the NLRP3/IL‐1β signaling axis in microglia to alleviate ischemic blood‐brain barrier permeability by downregulating astrocyte‐derived VEGF in rats

INTRODUCTION: The aim of this study was to explore whether the antibrain edema of hypertonic saline (HS) is associated with alleviating ischemic blood‐brain barrier (BBB) permeability by downregulating astrocyte‐derived vascular endothelial growth factor (VEGF), which is mediated by microglia‐derive...

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Publicat a:CNS Neurosci Ther
Autors principals: Wang, Qiao‐sheng, Ding, Hong‐guang, Chen, Sheng‐long, Liu, Xin‐qiang, Deng, Yi‐yu, Jiang, Wen‐qiang, Li, Ya, Huang, Lin‐qiang, Han, Yong‐li, Wen, Miao‐yun, Wang, Mei‐qiu, Zeng, Hong‐ke
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539845/
https://ncbi.nlm.nih.gov/pubmed/32529750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13427
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