Hypertonic saline mediates the NLRP3/IL‐1β signaling axis in microglia to alleviate ischemic blood‐brain barrier permeability by downregulating astrocyte‐derived VEGF in rats

INTRODUCTION: The aim of this study was to explore whether the antibrain edema of hypertonic saline (HS) is associated with alleviating ischemic blood‐brain barrier (BBB) permeability by downregulating astrocyte‐derived vascular endothelial growth factor (VEGF), which is mediated by microglia‐derive...

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Veröffentlicht in:CNS Neurosci Ther
Hauptverfasser: Wang, Qiao‐sheng, Ding, Hong‐guang, Chen, Sheng‐long, Liu, Xin‐qiang, Deng, Yi‐yu, Jiang, Wen‐qiang, Li, Ya, Huang, Lin‐qiang, Han, Yong‐li, Wen, Miao‐yun, Wang, Mei‐qiu, Zeng, Hong‐ke
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539845/
https://ncbi.nlm.nih.gov/pubmed/32529750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13427
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