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Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
BACKGROUND: The development of antinociceptive tolerance following repetitive administration of opioid analgesics significantly hinders their clinical use. Evidence has accumulated indicating that microglia within the spinal cord plays a critical role in morphine tolerance. The inhibitor of microgli...
Gespeichert in:
| Veröffentlicht in: | J Neuroinflammation |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4774188/ https://ncbi.nlm.nih.gov/pubmed/26931361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0520-z |
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