Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia

BACKGROUND: The development of antinociceptive tolerance following repetitive administration of opioid analgesics significantly hinders their clinical use. Evidence has accumulated indicating that microglia within the spinal cord plays a critical role in morphine tolerance. The inhibitor of microgli...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Cai, Yang, Kong, Hong, Pan, Yin-Bing, Jiang, Lai, Pan, Xiu-Xiu, Hu, Liang, Qian, Yan-Ning, Jiang, Chun-Yi, Liu, Wen-Tao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774188/
https://ncbi.nlm.nih.gov/pubmed/26931361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0520-z
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