Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation

Morphine is frequently used for pain relief, but long-term morphine therapy in patients with chronic pain results in analgesic tolerance and hyperalgesia. There are no effective therapeutic treatments that limit these detrimental side effects. We found pretreatment with melatonin could decrease morp...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Liu, Qianjin, Su, Ling-Yan, Sun, Chunli, Jiao, Lijin, Miao, Ying, Xu, Min, Luo, Rongcan, Zuo, Xin, Zhou, Rongbin, Zheng, Ping, Xiong, Wei, Xue, Tian, Yao, Yong-Gang
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225735/
https://ncbi.nlm.nih.gov/pubmed/32413745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101560
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