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Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation
Morphine is frequently used for pain relief, but long-term morphine therapy in patients with chronic pain results in analgesic tolerance and hyperalgesia. There are no effective therapeutic treatments that limit these detrimental side effects. We found pretreatment with melatonin could decrease morp...
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| 出版年: | Redox Biol |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7225735/ https://ncbi.nlm.nih.gov/pubmed/32413745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101560 |
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