Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation

BACKGROUND: Hypertonic saline (HS) has been successfully used clinically for treatment of various forms of cerebral edema. Up-regulated expression of Na-K-Cl Cotransporter 1 (NKCC1) and inflammatory mediators such as tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) has been demonst...

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Hlavní autoři: Huang, Lin-Qiang, Zhu, Gao-Feng, Deng, Yi-Yu, Jiang, Wen-Qiang, Fang, Ming, Chen, Chun-Bo, Cao, Wei, Wen, Miao-Yun, Han, Yong-Li, Zeng, Hong-Ke
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080704/
https://ncbi.nlm.nih.gov/pubmed/24916922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-102
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