FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity

IgG immune complexes (ICs) promote autoimmunity through binding fragment crystallizable (Fc) γ-receptors (FcγRs). Of these, the highly prevalent FcγRIIa (CD32a) histidine (H)-131 variant (CD32a(H)) is strongly linked to human autoimmune diseases through unclear mechanisms. We show that, relative to...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Hubbard, Jonathan J., Pyzik, Michal, Rath, Timo, Kozicky, Lisa K., Sand, Kine M.K., Gandhi, Amit K., Grevys, Algirdas, Foss, Stian, Menzies, Susan C., Glickman, Jonathan N., Fiebiger, Edda, Roopenian, Derry C., Sandlie, Inger, Andersen, Jan Terje, Sly, Laura M., Baker, Kristi, Blumberg, Richard S.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537387/
https://ncbi.nlm.nih.gov/pubmed/32658257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200359
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