FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity

IgG immune complexes (ICs) promote autoimmunity through binding fragment crystallizable (Fc) γ-receptors (FcγRs). Of these, the highly prevalent FcγRIIa (CD32a) histidine (H)-131 variant (CD32a(H)) is strongly linked to human autoimmune diseases through unclear mechanisms. We show that, relative to...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Hubbard, Jonathan J., Pyzik, Michal, Rath, Timo, Kozicky, Lisa K., Sand, Kine M.K., Gandhi, Amit K., Grevys, Algirdas, Foss, Stian, Menzies, Susan C., Glickman, Jonathan N., Fiebiger, Edda, Roopenian, Derry C., Sandlie, Inger, Andersen, Jan Terje, Sly, Laura M., Baker, Kristi, Blumberg, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537387/
https://ncbi.nlm.nih.gov/pubmed/32658257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200359
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