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FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity

IgG immune complexes (ICs) promote autoimmunity through binding fragment crystallizable (Fc) γ-receptors (FcγRs). Of these, the highly prevalent FcγRIIa (CD32a) histidine (H)-131 variant (CD32a(H)) is strongly linked to human autoimmune diseases through unclear mechanisms. We show that, relative to...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Hubbard, Jonathan J., Pyzik, Michal, Rath, Timo, Kozicky, Lisa K., Sand, Kine M.K., Gandhi, Amit K., Grevys, Algirdas, Foss, Stian, Menzies, Susan C., Glickman, Jonathan N., Fiebiger, Edda, Roopenian, Derry C., Sandlie, Inger, Andersen, Jan Terje, Sly, Laura M., Baker, Kristi, Blumberg, Richard S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537387/
https://ncbi.nlm.nih.gov/pubmed/32658257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200359
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