Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

BACKGROUND: Chromodomain helicase DNA-binding protein 8 (Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 haploinsufficiency impairs gene expression in the brain and impacts behavior at different stages of life is unknown. METHODS: We generated a mutant mous...

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Détails bibliographiques
Publié dans:Mol Autism
Auteurs principaux: Jiménez, Jessica A., Ptacek, Travis S., Tuttle, Alex H., Schmid, Ralf S., Moy, Sheryl S., Simon, Jeremy M., Zylka, Mark J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
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Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537101/
https://ncbi.nlm.nih.gov/pubmed/33023670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00369-8
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