Delineation of molecular determinants for FR900359 inhibition of G(q/11) unlocks inhibition of Gα(s)

Heterotrimeric G proteins are essential mediators of intracellular signaling of G protein–coupled receptors. The G(q/11) subfamily consists of G(q), G(11), G(14), and G(16) proteins, of which all but G(16) are inhibited by the structurally related natural products YM-254890 and FR900359. These inhib...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Boesgaard, Michael W., Harpsøe, Kasper, Malmberg, Michelle, Underwood, Christina R., Inoue, Asuka, Mathiesen, Jesper M., König, Gabriele M., Kostenis, Evi, Gloriam, David E., Bräuner-Osborne, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535923/
https://ncbi.nlm.nih.gov/pubmed/32753482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013002
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