Effects of Oncogenic Gα(q) and Gα(11) Inhibition by FR900359 in Uveal Melanoma

Uveal melanoma is the most common intraocular tumor in adults and often metastasizes to the liver, leaving patients with few options. Recurrent activating mutations in the G proteins, Gα(q) and Gα(11), are observed in approximately 93% of all uveal melanomas. While therapeutic intervention of downst...

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Gepubliceerd in:Mol Cancer Res
Hoofdauteurs: Lapadula, Dominic, Farias, Eduardo, Randolph, Clinita E., Purwin, Timothy, McGrath, Dougan, Charpentier, Thomas, Zhang, Lihong, Wu, Shihua, Terai, Mizue, Sato, Takami, Tall, Gregory G., Zhou, Naiming, Wedegaertner, Philip B., Aplin, Andrew E., Aguirre-Ghiso, Julio, Benovic, Jeffrey L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445713/
https://ncbi.nlm.nih.gov/pubmed/30567972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0574
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