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R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities
Trinucleotide repeat (TNR) expansion and deletion are responsible for over 40 neurodegenerative diseases and associated with cancer. TNRs can undergo somatic instability that is mediated by DNA damage and repair and gene transcription. Recent studies have pointed toward a role for R-loops in causing...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7535915/ https://ncbi.nlm.nih.gov/pubmed/32763971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014161 |
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