R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities

Trinucleotide repeat (TNR) expansion and deletion are responsible for over 40 neurodegenerative diseases and associated with cancer. TNRs can undergo somatic instability that is mediated by DNA damage and repair and gene transcription. Recent studies have pointed toward a role for R-loops in causing...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Laverde, Eduardo E., Lai, Yanhao, Leng, Fenfei, Balakrishnan, Lata, Freudenreich, Catherine H., Liu, Yuan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
Ämnen:
DNA and Chromosomes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535915/
https://ncbi.nlm.nih.gov/pubmed/32763971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014161
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk