Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion

Trinucleotide repeat (TNR) expansion is responsible for numerous human neurodegenerative diseases. However, the underlying mechanisms remain unclear. Recent studies have shown that DNA base excision repair (BER) can mediate TNR expansion and deletion by removing base lesions in different locations o...

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Detalhes bibliográficos
Main Authors: Xu, Meng, Lai, Yanhao, Torner, Justin, Zhang, Yanbin, Zhang, Zunzhen, Liu, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973345/
https://ncbi.nlm.nih.gov/pubmed/24423876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1372
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