Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion

Trinucleotide repeat (TNR) expansion is responsible for numerous human neurodegenerative diseases. However, the underlying mechanisms remain unclear. Recent studies have shown that DNA base excision repair (BER) can mediate TNR expansion and deletion by removing base lesions in different locations o...

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Bibliografiset tiedot
Päätekijät: Xu, Meng, Lai, Yanhao, Torner, Justin, Zhang, Yanbin, Zhang, Zunzhen, Liu, Yuan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2014
Aiheet:
Genome Integrity, Repair and Replication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973345/
https://ncbi.nlm.nih.gov/pubmed/24423876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1372
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