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Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
Studies in knockout mice provide evidence that MSH2–MSH3 and the BER machinery promote trinucleotide repeat (TNR) expansion, yet how these two different repair pathways cause the mutation is unknown. Here we report the first molecular crosstalk mechanism, in which MSH2–MSH3 is used as a component of...
Gorde:
| Argitaratua izan da: | Nat Commun |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4996945/ https://ncbi.nlm.nih.gov/pubmed/27546332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12465 |
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