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AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair
Base excision repair (BER) of an oxidized base within a trinucleotide repeat (TNR) tract can lead to TNR expansions that are associated with over 40 human neurodegenerative diseases. This occurs as a result of DNA secondary structures such as hairpins formed during repair. We have previously shown t...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4499148/ https://ncbi.nlm.nih.gov/pubmed/25990721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv530 |
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