AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair

Base excision repair (BER) of an oxidized base within a trinucleotide repeat (TNR) tract can lead to TNR expansions that are associated with over 40 human neurodegenerative diseases. This occurs as a result of DNA secondary structures such as hairpins formed during repair. We have previously shown t...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Beaver, Jill M., Lai, Yanhao, Xu, Meng, Casin, Astrid H., Laverde, Eduardo E., Liu, Yuan
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499148/
https://ncbi.nlm.nih.gov/pubmed/25990721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv530
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