New classes of potent heparanase inhibitors from ligand-based virtual screening

Heparanase is a validated target in cancer therapy and a potential target for several inflammatory pathologies. A ligand-based virtual screening of commercial libraries was performed to expand the chemical space of small-molecule inhibitors. The screening was based on similarity with known inhibitor...

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Publié dans:J Enzyme Inhib Med Chem
Auteurs principaux: Pala, Daniele, Scalvini, Laura, Elisi, Gian Marco, Lodola, Alessio, Mor, Marco, Spadoni, Gilberto, Ferrara, Fabiana F., Pavoni, Emiliano, Roscilli, Giuseppe, Milazzo, Ferdinando M., Battistuzzi, Gianfranco, Rivara, Silvia, Giannini, Giuseppe
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534336/
https://ncbi.nlm.nih.gov/pubmed/32907434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1811701
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