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Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase
Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes. A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development...
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| Publicat a: | Glycobiology |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4847616/ https://ncbi.nlm.nih.gov/pubmed/26762172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cww003 |
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