Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase

Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes. A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Glycobiology
Asıl Yazarlar: Pala, Daniele, Rivara, Silvia, Mor, Marco, Milazzo, Ferdinando Maria, Roscilli, Giuseppe, Pavoni, Emiliano, Giannini, Giuseppe
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2016
Konular:
ORIGINAL ARTICLES
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847616/
https://ncbi.nlm.nih.gov/pubmed/26762172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cww003
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