Immunization with Mycobacterium tuberculosis–Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette–Guérin Vaccination and Improves Protection in Mice

Despite the fact that the majority of people in tuberculosis (TB)–endemic areas are vaccinated with the Bacillus Calmette–Guérin (BCG) vaccine, TB remains the leading infectious cause of death. Data from both animal models and humans show that BCG and subunit vaccines induce T cells of different phe...

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Vydáno v:J Immunol
Hlavní autoři: Aagaard, Claus, Knudsen, Niels Peter Hell, Sohn, Iben, Izzo, Angelo A., Kim, Hongmin, Kristiansen, Emma Holsey, Lindenstrøm, Thomas, Agger, Else Marie, Rasmussen, Michael, Shin, Sung Jae, Rosenkrands, Ida, Andersen, Peter, Mortensen, Rasmus
Médium: Artigo
Jazyk:Inglês
Vydáno: AAI 2020
Témata:
Immunotherapy and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533711/
https://ncbi.nlm.nih.gov/pubmed/32887748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000563
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