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The mode of action of the Protein tyrosine phosphatase 1B inhibitor Ertiprotafib

Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for the treatment of diabetes and obesity. Ertiprotafib is a PTP1B inhibitor that reached the clinical trial stage for the treatment of diabetes. Interestingly, Ertiprotafib reduces the melting temperature of PTP1B in differen...

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Pubblicato in:PLoS One
Autori principali: Kumar, Ganesan Senthil, Page, Rebecca, Peti, Wolfgang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531832/
https://ncbi.nlm.nih.gov/pubmed/33007022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240044
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