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Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure Based Drug Design of Serine/Threonine Phosphatase Inhibitors
Protein Phosphatase 1 is ubiquitously distributed throughout all tissues and regulates many diverse pathways ranging from cell cycle progression to carbohydrate metabolism. Many naturally occurring, molecular toxins modulate PP1 activity, though the exact mechanism of this differential regulation is...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652124/ https://ncbi.nlm.nih.gov/pubmed/18992256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.053 |
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