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Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure Based Drug Design of Serine/Threonine Phosphatase Inhibitors

Protein Phosphatase 1 is ubiquitously distributed throughout all tissues and regulates many diverse pathways ranging from cell cycle progression to carbohydrate metabolism. Many naturally occurring, molecular toxins modulate PP1 activity, though the exact mechanism of this differential regulation is...

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Detalhes bibliográficos
Main Authors: Kelker, Matthew S., Page, Rebecca, Peti, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652124/
https://ncbi.nlm.nih.gov/pubmed/18992256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.053
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