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Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure Based Drug Design of Serine/Threonine Phosphatase Inhibitors

Protein Phosphatase 1 is ubiquitously distributed throughout all tissues and regulates many diverse pathways ranging from cell cycle progression to carbohydrate metabolism. Many naturally occurring, molecular toxins modulate PP1 activity, though the exact mechanism of this differential regulation is...

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Bibliografiske detaljer
Main Authors: Kelker, Matthew S., Page, Rebecca, Peti, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652124/
https://ncbi.nlm.nih.gov/pubmed/18992256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.053
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