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Strategies to make Protein Serine/Threonine (PP1, Calcineurin) and Tyrosine Phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites
The established dogma is that protein Serine/Threonine (PSPs) and Tyrosine (PTPs) Phosphatases are unattainable drug targets. This is because natural product inhibitors of PSP active sites are lethal, while the active sites of PTPs are exceptionally conserved and charged, making it nearly impossible...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4451382/ https://ncbi.nlm.nih.gov/pubmed/25771485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.040 |
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