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Strategies to make Protein Serine/Threonine (PP1, Calcineurin) and Tyrosine Phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites

The established dogma is that protein Serine/Threonine (PSPs) and Tyrosine (PTPs) Phosphatases are unattainable drug targets. This is because natural product inhibitors of PSP active sites are lethal, while the active sites of PTPs are exceptionally conserved and charged, making it nearly impossible...

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Bibliographische Detailangaben
Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Peti, Wolfgang, Page, Rebecca
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451382/
https://ncbi.nlm.nih.gov/pubmed/25771485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.040
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