Tofacitinib inhibits the development of experimental autoimmune uveitis and reduces the proportions of Th1 but not of Th17 cells

PURPOSE: Tofacitinib is a pan-Janus kinase (JAK) inhibitor that suppresses cytokine signaling and in turn, the cells that participate in inflammatory immunopathogenic processes. We examined the capacity of tofacitinib to inhibit the induction of experimental autoimmune uveitis (EAU) and related immu...

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Bibliografske podrobnosti
izdano v:Mol Vis
Main Authors: Bing, So Jin, Lyu, Cancan, Xu, Biying, Wandu, Wambui S., Hinshaw, Samuel J., Furumoto, Yasuko, Caspi, Rachel R., Gadina, Massimo, Gery, Igal
Format: Artigo
Jezik:Inglês
Izdano: Molecular Vision 2020
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531779/
https://ncbi.nlm.nih.gov/pubmed/33088168
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