Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response

BACKGROUND: Mutations in LRRK2 are related to certain forms of Parkinson’s disease and, possibly, to the pathogenesis of Crohn’s disease. In both these diseases inflammatory processes participate in the pathogenic process. LRRK2 is expressed in lymphoid cells and, interestingly, Lrrk2 (-/-) mice wer...

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Publicado en:PLoS One
Main Authors: Wandu, Wambui S., Tan, Cuiyan, Ogbeifun, Osato, Vistica, Barbara P., Shi, Guangpu, Hinshaw, Samuel J. H., Xie, Chengsong, Chen, Xi, Klinman, Dennis M., Cai, Huaibin, Gery, Igal
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465928/
https://ncbi.nlm.nih.gov/pubmed/26067490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128906
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