Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow–Derived Cells Differ Markedly in Their Production of IL-1β and IL-18

PURPOSE. The inflammatory process plays a major role in the pathogenesis of AMD, and recent data indicate the involvement of inflammasomes. Inflammasomes are intracellular structures that trigger inflammation by producing mature interleukin-(IL)-1β and IL-18. This study examined the capacity of 7-ke...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Shi, Guangpu, Chen, Siqi, Wandu, Wambui S., Ogbeifun, Osato, Nugent, Lindsey F., Maminishkis, Arvydas, Hinshaw, Samuel J. H., Rodriguez, Ignacio R., Gery, Igal
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354246/
https://ncbi.nlm.nih.gov/pubmed/25678688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14557
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