Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity

The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody. In addition, FcRn is known to traffic antigen-bound immunoglobulins (Ag-IgGs), and to interact with immune complexes to facilitate t...

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Vydáno v:MAbs
Hlavní autoři: Sun, Yue, Estevez, Alberto, Schlothauer, Tilman, Wecksler, Aaron T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531492/
https://ncbi.nlm.nih.gov/pubmed/32795110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1802135
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