Exosomal miR‐1255b‐5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial‐to‐mesenchymal transition

Cancer cells undergo epithelial‐to‐mesenchymal transition (EMT) in response to hypoxia. Exosomes produced in tumor microenvironments carry microRNAs (miRNAs) that affect proliferation, metastasis, and EMT. Hypoxic regulation of EMT is associated with telomerase content and stability, but the underly...

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Vydáno v:Mol Oncol
Hlavní autoři: Zhang, Xue, Bai, Jian, Yin, Hang, Long, Long, Zheng, Zhewen, Wang, Qingqing, Chen, Fengxia, Yu, Xiaoyan, Zhou, Yunfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530775/
https://ncbi.nlm.nih.gov/pubmed/32679610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12765
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