PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia

The immune checkpoint inhibitor programmed cell death protein 1 (PD-1) plays a critical role in immune regulation. Recent studies have demonstrated functional PD-1 expression in peripheral sensory neurons, which contributes to neuronal excitability, pain, and opioid analgesia. Here we report neurona...

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Bibliografske podrobnosti
izdano v:iScience
Main Authors: Jiang, Changyu, Wang, Zilong, Donnelly, Christopher R., Wang, Kaiyuan, Andriessen, Amanda S., Tao, Xueshu, Matsuda, Megumi, Zhao, Junli, Ji, Ru-Rong
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530307/
https://ncbi.nlm.nih.gov/pubmed/33083737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101570
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