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Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates

Emerging immunotherapies with monoclonal antibodies against programmed cell death protein-1 (PD-1) have shown success in treating cancers. However, PD-1 signaling in neurons is largely unknown. We recently reported that dorsal root ganglion (DRG) primary sensory neurons express PD-1 and activation o...

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Bibliografiska uppgifter
I publikationen:Sci Transl Med
Huvudupphovsmän: Wang, Zilong, Jiang, Changyu, He, Qianru, Matsuda, Megumi, Han, Qingjian, Wang, Kaiyuan, Bang, Sangsu, Ding, Huiping, Ko, Mei-Chuan, Ji, Ru-Rong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536651/
https://ncbi.nlm.nih.gov/pubmed/32075945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw6471
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