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Optimization of S. aureus dCas9 and CRISPRi Elements for a Single Adeno-Associated Virus that Targets an Endogenous Gene
The power of CRISPRi to decrease targeted gene expression for clinical applications has been inhibited by delivery challenges. Existing constructs are too large to fit within the ∼4.7 kb packaging size limitation of adeno-associated virus (AAV), the only FDA approved viral vector for clinical use. T...
Tallennettuna:
| Julkaisussa: | Mol Ther Methods Clin Dev |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society of Gene & Cell Therapy
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7530248/ https://ncbi.nlm.nih.gov/pubmed/33024795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.09.001 |
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