Respiratory pathology in the Optn(−/−) mouse model of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder that results in death due to respiratory failure. Many genetic defects are associated with ALS; one such defect is a mutation in the gene encoding optineurin (OPTN). Using an optineurin null mouse (Optn(−/−)), we sought...

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Pubblicato in:Respir Physiol Neurobiol
Autori principali: McCall, Angela L., Dhindsa, Justin S., Pucci, Logan A., Kahn, Amanda F., Fusco, Anna F., Biswas, Debolina D., Strickland, Laura M., Tseng, Henry C., ElMallah, Mai K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530116/
https://ncbi.nlm.nih.gov/pubmed/32805420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2020.103525
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