Novel HIV-1 Capsid-Targeting Small Molecules of the PF74 Binding Site

The PF74 binding site in HIV-1 capsid protein (CA) is a compelling antiviral drug target. Although PF74 confers mechanistically distinct antiviral phenotypes by competing against host factors for CA binding, it suffers from prohibitively low metabolic stability. Therefore, there has been increasing...

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Enregistré dans:
Détails bibliographiques
Publié dans:Eur J Med Chem
Auteurs principaux: Wang, Lei, Casey, Mary C., Vernekar, Sanjeev Kumar V., Sahani, Rajkumar Lalji, Kankanala, Jayakanth, Kirby, Karen A., Du, Haijuan, Hachiya, Atsuko, Zhang, Huanchun, Tedbury, Philip R., Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530112/
https://ncbi.nlm.nih.gov/pubmed/32814250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112626
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