Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication. However, the prohibitively low metabolic stabi...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Wang, Lei, Casey, Mary C., Vernekar, Sanjeev Kumar V., Sahani, Rajkumar Lalji, Kirby, Karen A., Du, Haijuan, Zhang, Huanchun, Tedbury, Philip R., Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982424/
https://ncbi.nlm.nih.gov/pubmed/33777683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.07.016
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