Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74

Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 could further the understanding of ligand binding modes, diversify ligand chemical classes, and allow identification of new...

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Detalhes bibliográficos
Publicado no:Viruses
Main Authors: Sahani, Rajkumar Lalji, Diana-Rivero, Raquel, Vernekar, Sanjeev Kumar V., Wang, Lei, Du, Haijuan, Zhang, Huanchun, Castaner, Andres Emanuelli, Casey, Mary C., Kirby, Karen A., Tedbury, Philip R., Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000227/
https://ncbi.nlm.nih.gov/pubmed/33804121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v13030479
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