Novel HIV-1 Capsid-Targeting Small Molecules of the PF74 Binding Site

The PF74 binding site in HIV-1 capsid protein (CA) is a compelling antiviral drug target. Although PF74 confers mechanistically distinct antiviral phenotypes by competing against host factors for CA binding, it suffers from prohibitively low metabolic stability. Therefore, there has been increasing...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Wang, Lei, Casey, Mary C., Vernekar, Sanjeev Kumar V., Sahani, Rajkumar Lalji, Kankanala, Jayakanth, Kirby, Karen A., Du, Haijuan, Hachiya, Atsuko, Zhang, Huanchun, Tedbury, Philip R., Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530112/
https://ncbi.nlm.nih.gov/pubmed/32814250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112626
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