Structural basis of Focal Adhesion Kinase activation on lipid membranes

Focal adhesion kinase (FAK) is a key component of the membrane proximal signaling layer in focal adhesion complexes, regulating important cellular processes, including cell migration, proliferation, and survival. In the cytosol, FAK adopts an autoinhibited state but is activated upon recruitment int...

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Pubblicato in:EMBO J
Autori principali: Acebrón, Iván, Righetto, Ricardo D, Schoenherr, Christina, de Buhr, Svenja, Redondo, Pilar, Culley, Jayne, Rodríguez, Carlos F, Daday, Csaba, Biyani, Nikhil, Llorca, Oscar, Byron, Adam, Chami, Mohamed, Gräter, Frauke, Boskovic, Jasminka, Frame, Margaret C, Stahlberg, Henning, Lietha, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527928/
https://ncbi.nlm.nih.gov/pubmed/32779739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104743
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