Impact of mutations in homologous recombination repair genes on treatment outcomes for metastatic castration resistant prostate cancer

INTRODUCTION: A significant proportion of patients with metastatic castration-resistant prostate cancer (mCRPC) harbor mutations in homologous recombination (HR) repair genes, with some of these mutations associating with increased tumor susceptibility to poly(ADP-ribose) polymerase (PARP) inhibitor...

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Publicat a:PLoS One
Autors principals: Carlson, Alexander S., Acevedo, Rigo I., Lim, Daniel M., Gulati, Roman, Gawne, Agnes, Sokolova, Alexandra O., Cheng, Heather H., Nelson, Peter S., Montgomery, R. Bruce, Yu, Evan Y., Schweizer, Michael T.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526881/
https://ncbi.nlm.nih.gov/pubmed/32997692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239686
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