Impact of mutations in homologous recombination repair genes on treatment outcomes for metastatic castration resistant prostate cancer

INTRODUCTION: A significant proportion of patients with metastatic castration-resistant prostate cancer (mCRPC) harbor mutations in homologous recombination (HR) repair genes, with some of these mutations associating with increased tumor susceptibility to poly(ADP-ribose) polymerase (PARP) inhibitor...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Carlson, Alexander S., Acevedo, Rigo I., Lim, Daniel M., Gulati, Roman, Gawne, Agnes, Sokolova, Alexandra O., Cheng, Heather H., Nelson, Peter S., Montgomery, R. Bruce, Yu, Evan Y., Schweizer, Michael T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526881/
https://ncbi.nlm.nih.gov/pubmed/32997692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239686
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