Mismatch repair deficiency in metastatic prostate cancer: Response to PD-1 blockade and standard therapies

BACKGROUND: While response rates to anti-PD1 therapy are low in unselected metastatic castration resistant prostate cancer (mCRPC) patients, those with inactivating mutations in mismatch repair (MMR) genes (i.e. MMR deficiency; MMRd) or microsatellite instability (MSI) are thought likely to respond...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Graham, Laura S., Montgomery, Bruce, Cheng, Heather H., Yu, Evan Y., Nelson, Peter S., Pritchard, Colin, Erickson, Stephanie, Alva, Ajjai, Schweizer, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250457/
https://ncbi.nlm.nih.gov/pubmed/32453797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233260
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