Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α

Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part mediated by free radicals. In...

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Dades bibliogràfiques
Publicat a:Oxid Med Cell Longev
Autors principals: Picón-Pagès, Pol, Gutiérrez, Daniela A., Barranco-Almohalla, Alejandro, Crepin, Giulia, Tajes, Marta, ILL-Raga, Gerard, Guix, Francesc X., Menéndez, Silvia, Arumí-Uría, Montserrat, Vicente, Rubén, Álvarez, Alejandra R., Muñoz, Francisco J.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525306/
https://ncbi.nlm.nih.gov/pubmed/33014268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/2739459
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