Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α

Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part mediated by free radicals. In...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Picón-Pagès, Pol, Gutiérrez, Daniela A., Barranco-Almohalla, Alejandro, Crepin, Giulia, Tajes, Marta, ILL-Raga, Gerard, Guix, Francesc X., Menéndez, Silvia, Arumí-Uría, Montserrat, Vicente, Rubén, Álvarez, Alejandra R., Muñoz, Francisco J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525306/
https://ncbi.nlm.nih.gov/pubmed/33014268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/2739459
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